胸腺基质淋巴细胞生成素
特应性皮炎
免疫系统
T辅助细胞
免疫学
医学
T细胞
作者
Xianxian Wu,Jinxuan Liu,Chaoqin Chen,Zhen Huang,Yuhui Zang,Jiangning Chen,Lei Dong,Junfeng Zhang,Zhi Ding
标识
DOI:10.1016/j.molimm.2020.11.013
摘要
Atopic dermatitis is a severe, chronic relapsing inflammatory disease of the skin with family clustering. It is characterized into acute phase, which is dominated by T helper 2-type immune responses, and chronic phase, which is dominated by T helper 1-type immune responses. Studies have shown that 3,3′-diindolylmethane not only has antitumor effects but also can relieve symptoms of inflammatory diseases by inhibiting the nuclear factor-κB signaling pathway and regulating T cell differentiation. To study the effect of 3,3′-diindolylmethane on atopic dermatitis and the underlying mechanism, a mouse model of acute atopic dermatitis was established using 2,4-dinitrofluorobenzene. After intraperitoneal injection of 3,3′-diindolylmethane, skin erythema and edema in mice were significantly alleviated. Furthermore, 3,3′-diindolylmethane reduced immune activation, probably by inhibiting the secretion of thymic stromal lymphopoietin by keratinocytes. 3,3′-Diindolylmethane also promoted the differentiation of regulatory T cells and inhibited the activation of T helper 2 and T helper 17 cells to reduce atopic dermatitis-related immune responses. However, it showed no significant effect on the differentiation of T helper 1 cells. These results indicate that 3,3′-diindolylmethane has a significant inhibitory effect on T helper 2 cells in the acute phase of atopic dermatitis. Our findings may provide not only more insights into the pathological mechanism of AD, but also a new candidate medicine for it.
科研通智能强力驱动
Strongly Powered by AbleSci AI