疾病
发病机制
转录组
选择性拼接
基因表达谱
RNA剪接
亨廷顿病
生物
基因表达
神经科学
基因
生物信息学
计算生物学
医学
遗传学
核糖核酸
病理
信使核糖核酸
免疫学
作者
Eliza Courtney,Shan Kornfeld,Karolina Janitz,Michał Janitz
标识
DOI:10.1016/j.jneumeth.2010.08.018
摘要
Changes in gene expression and splicing patterns (that occur prior to the onset and during the progression of complex diseases) have become a major focus of neurodegenerative disease research. These signature patterns of gene expression provide clues about the mechanisms involved in the molecular pathogenesis of neurodegenerative disease and may facilitate the discovery of novel therapeutic drugs. With the development of array technologies and the very recent RNA-seq technique, our understanding of the pathogenesis of neurodegenerative disease is expanding exponentially. Here, we review the technologies involved in gene expression and splicing analysis and the related literature on three common neurodegenerative diseases: Alzheimer's disease, Parkinson's disease and Huntington's disease.
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