神经影像学
线索反应性
上瘾
反应性(心理学)
心理学
神经科学
意识的神经相关物
认知心理学
认知
医学
渴求
病理
替代医学
作者
Agnes J. Jasinska,Elliot A. Stein,Jochen Kaiser,Marcus J. Naumer,Yavor Yalachkov
标识
DOI:10.1016/j.neubiorev.2013.10.013
摘要
Human neuroimaging studies suggest that neural cue reactivity is strongly associated with indices of drug use, including addiction severity and treatment success. However, little is known about factors that modulate cue reactivity. The goal of this review, in which we survey published fMRI and PET studies on drug cue reactivity in cocaine, alcohol, and tobacco cigarette users, is to highlight major factors that modulate brain reactivity to drug cues. First, we describe cue reactivity paradigms used in neuroimaging research and outline the brain circuits that underlie cue reactivity. We then discuss major factors that have been shown to modulate cue reactivity and review specific evidence as well as outstanding questions related to each factor. Building on previous model-building reviews on the topic, we then outline a simplified model that includes the key modulatory factors and a tentative ranking of their relative impact. We conclude with a discussion of outstanding challenges and future research directions, which can inform future neuroimaging studies as well as the design of treatment and prevention programs.
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