去神经支配
结缔组织
解剖
比目鱼肌
趾长伸肌
萎缩
指伸肌
生物
化学
肌梭
内科学
心肌细胞
有丝分裂
内分泌学
骨骼肌
医学
细胞生物学
遗传学
传入的
作者
Henning Schmalbruch,D. M. Lewis
出处
期刊:Muscle & Nerve
[Wiley]
日期:2000-04-01
卷期号:23 (4): 617-626
被引量:212
标识
DOI:10.1002/(sici)1097-4598(200004)23:4<617::aid-mus22>3.0.co;2-y
摘要
The mitotic activity in muscles of growing rats and the effect of denervation were studied by means of continuous infusion of 5-bromo-2-deoxyuridine (BRDU). Denervated muscles after 10 weeks contained 20 to 60% fewer muscle nuclei than normal; BRDU labeled about 25% of the nuclei of normal soleus and extensor digitorum longus (EDL) and of denervated EDL muscles but only 5% in the denervated soleus muscle. Labeled nuclei persisted in denervated but not in normal muscles. After the main growth period, the turnover of myonuclei was at most 1 to 2% per week. The behavior of connective tissue nuclei was similar to that in muscle fibers. Infusion of BRDU had no effect on contractile properties. It is suggested that the exceptionally rapid atrophy of the denervated rat soleus associated with loss of satellite cells was due to loss of myonuclei and differentiation and fusion of satellite cells. The cause may possibly be that the phase of postdenervation fibrillation is shorter than in other muscles. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 617–626, 2000.
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