Chemistry for DOTA Peptide Labeling at Phenylalanine Residues: On the Road to Preparing Peptide Ligand Tagged Libraries

Different synthetic strategies to control the position of DOTA in phenylalanine residues within a peptide sequence were studied and compared. The results showed that use of DOTA pre-labeled amino acids stands as the most promising procedure for the synthesis of peptide ligand tagged libraries by solid phase peptide synthesis. Keywords: peptide, dota, tag, phenylalanine, mri