介电谱
检出限
生物传感器
电化学
肝素
电极
材料科学
线性范围
肽
电化学气体传感器
电阻抗
色谱法
分析化学(期刊)
化学
纳米技术
生物化学
电气工程
工程类
物理化学
作者
Fanyu Meng,Weiguo Liang,Haixuan Sun,Ligang Wu,Xiao Gong,Peng Miao
标识
DOI:10.1002/celc.201600680
摘要
Abstract The first peptide‐based electrochemical biosensor for the measurement of the anti‐coagulant heparin using electrochemical impedance spectroscopy is reported. The peptide immobilized on the electrode interface specially captures heparin with high affinity. The composites formed on the electrode can thus effectively repel electrochemical species, leading to an increase in interfacial charge transfer resistance. After analyzing the electrochemical signals, a linear detection range from 0.05 to 10.0 μg/mL is obtained. The detection limit is calculated to be 0.01 μg/mL, which is extremely low with such a simple sensing mechanism. Moreover, the proposed method has potential application for sensitive and separation‐free detection of heparin in whole‐blood samples.
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