C-C趋化因子受体7型
CD8型
细胞毒性T细胞
免疫系统
肝损伤
T细胞
生物
趋化因子
获得性免疫系统
免疫学
CXCL16型
过继性细胞移植
趋化因子受体
内分泌学
生物化学
体外
作者
Patricia M. Niemietz,Moritz Peiseler,Marlene Kohlhepp,Paul Horn,Kylie P. Matchett,Yuting Wang,Leon Haas,Tianjiao Zhang,Alix Bruneau,Adrien Guillot,Hilmar Berger,Anke Liepelt,Klaudia Theresa Warzecha,Catharina Demske,Diana Möckel,Twan Lammers,Neil C. Henderson,Felix Heymann,Frank Tacke
出处
期刊:Hepatology
[Lippincott Williams & Wilkins]
日期:2024-01-17
卷期号:80 (5): 1104-1119
被引量:10
标识
DOI:10.1097/hep.0000000000000757
摘要
Our study demonstrates the involvement of the adaptive immune system in ALF in humans and mice. We identify the CCR7-CCL21 axis as an important regulatory pathway, providing downstream protection against T cell-mediated liver injury.
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