Revolutionising shift in advanced wound healing therapies: nanoengineered herbal gels

Recent advancements in nanogel formulations have significantly enhanced the therapeutic efficacy of herbal medicines in wound healing applications. This systematic review explores the integration of various herbal extracts and bioactive compounds into nano gels, highlighting their improved properties and wound healing application. Key formulations include tobacco stem nanogels demonstrating stability and rapid wound contraction, neem and silk fibroin hydrogels accelerating wound regeneration, and curcumin nanosuspension-based nanogels significantly enhancing wound contraction rates. Additional formulations, such as Sansevieria trifasciata hydrogels and emodin-based double network hydrogels, showed substantial reductions in wound size and increased cell proliferation. The incorporation of herbal extracts and bioactive compounds like Bletilla striata, curcumin, calendula, and Hibiscus rosa-sinensis further exhibited enhanced coagulation, antioxidant effects, and fibroblast proliferation. This review highlights the promising future of herbal nanogels in biomedical applications, offering a synergistic approach that combines the benefits of traditional herbal medicine with advanced nanotechnology.