We conducted a modified case-crossover study to examine whether wildfires in the Paraná River Delta departments surrounding Rosario, Argentina, during 2021-2022 increased PM₂.₅ concentrations in this city and if this rise subsequently elevated the risk of ST-elevation myocardial infarction (STEMI). We first observed that daily PM₂.₅ levels in Rosario were significantly higher on wildfire days compared to non-wildfire days (34 µg/m