白细胞粘附缺陷
慢性肉芽肿性疾病
免疫学
髓过氧化物酶
趋化性
医学
原发性免疫缺陷
呼吸爆发
疾病
炎症
病理
免疫系统
内科学
受体
整合素αM
CD18型
出处
期刊:Methods in molecular biology
日期:2014-01-01
卷期号:: 501-515
被引量:51
标识
DOI:10.1007/978-1-62703-845-4_30
摘要
Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include the leukocyte adhesion deficiencies, actin defects, and other disorders of chemotaxis, hyperimmunoglobulin E syndrome, Chédiak–Higashi syndrome, neutrophil-specific granule deficiency, chronic granulomatous disease, and myeloperoxidase deficiency. Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder.
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