结晶
多态性(计算机科学)
三乙胺
吡喹酮
过饱和度
超临界流体
驱虫药
化学
溶剂
球磨机
结晶学
化学工程
材料科学
有机化学
血吸虫病
等位基因
蠕虫
工程类
基因
动物
生物
生物化学
生态学
作者
Marcellus G.F. de Moraes,Amaro Gomes Barreto,Argimiro Resende Secchi,Maurício B. de Souza,Paulo Laranjeira da Cunha Lage,Allan S. Myerson
标识
DOI:10.1021/acs.cgd.2c01381
摘要
Praziquantel (PZQ) is an anthelmintic first-line drug to treat schistosomiasis, a neglected tropical disease strongly related to poverty. PZQ crystalline structures and polymorphs have been studied mainly via mechanochemical approaches. This work applies a systematic study to investigate the polymorphism of PZQ using cooling crystallization experiments under different conditions not yet explored in the literature for this compound. We accessed all forms previously reported so far obtained via mechanochemistry and the hydrate found through supercritical CO2 processing. A novel dimethylacetamide (DMA) solvate was obtained, and a new form was discovered after desolvation of the DMA solvate by aging and exposure to water-vapor atmosphere. Toluene and triethylamine were solvents capable of enabling the formation of different forms depending on the employed experimental condition. A new form was discovered using triethylamine as solvent, which differs from all known polymorphs. The results of this work demonstrate that solvent selection and variation in the rate of supersaturation generation can generate forms obtained from more complicated techniques as well as potentially finding new forms.
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