光热治疗
化学
体内
生物医学中的光声成像
癌症研究
放射治疗
免疫疗法
癌症治疗
化疗
细胞凋亡
靶向治疗
癌症
纳米技术
医学
内科学
生物化学
材料科学
生物
物理
生物技术
光学
作者
Minghui Zhu,Xueyu Man,Yang Tongfu,Wenjuan Li,Shanhe Li,Gang Xu,Zhenlei Zhang,Hong Liang,Feng Yang
标识
DOI:10.1021/acs.jmedchem.3c01583
摘要
For the integration of targeted diagnosis and treatment of tumor, we innovatively designed and synthesized a single-molecule hetero-multinuclear Er(III)–Cu(II) complex (ErCu2) and then constructed an ErCu2@apoferritin (AFt) nanoparticle (NP) delivery system. ErCu2 and ErCu2@AFt NPs not only provided an evident photoacoustic imaging (PAI) signal of the tumor but also effectively inhibited tumor growth by integrating photothermal therapy, chemotherapy, and immunotherapy. ErCu2@AFt NPs improved the targeting ability and decreased the systemic toxicity of ErCu2 in vivo. Furthermore, we confirmed that ErCu2 and ErCu2@AFt NPs inhibited tumor growth by inducing apoptosis and autophagy of tumor cells and activating the immune system. The study not only provides a novel strategy to develop therapeutic metal agents but also reveals their potential for targeted accurate diagnosis and multimodality therapy of cancer.
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