[Research progress of chronic obstructive pulmonary disease in young people and pre-COPD].

Conventional wisdom holds that the onset of chronic obstructive pulmonary disease (COPD) is usually in older people. However, with extended follow-up in large cohort studies, the trajectory of lung function development has been gradually delineated, indicating that the decline of lung function may originate early in life. In addition, a large number of studies have shown that people with chronic respiratory symptoms, pulmonary imaging changes and abnormal lung physiology, but not in line with pulmonary function diagnosis of COPD, tend to develop COPD in the future and may have a worse prognosis, suggesting the necessity of early intervention. The GOLD 2022 report proposes a series of terms related to COPD, including COPD in young people and pre-COPD, opening up new opportunities for the prevention, early diagnosis and treatment of COPD. These concepts also guide the study design of the biological mechanism of COPD and the trajectory of disease progression. This article reviews the research progress of COPD in young people and pre-COPD to attract more attention in clinical practice.传统观念认为慢性阻塞性肺疾病（慢阻肺）通常是老年疾病。然而，随着大型队列研究随访时间的延长，人群肺功能发育轨迹得到了较完整的描绘，表明肺功能的下降可起源于生命早期。此外，大量研究表明，具有慢性呼吸道症状、肺部影像学改变和肺生理结构异常却不符合慢阻肺的肺功能诊断的人群，在未来有患慢阻肺的倾向且影响预后，提示早期干预的必要性。2022版全球慢性阻塞性肺病防治倡议提出了包括早发型慢阻肺和慢阻肺前期在内的一系列慢阻肺相关名词，为预防、早期诊断和治疗慢阻肺开辟了新的机会，同时为慢阻肺生物学机制、疾病进展轨迹的研究设计提供指引。本文总结了早发型慢阻肺和慢阻肺前期的研究进展，以期为临床早期防治慢阻肺提供参考。.