神经科学
光遗传学
投影(关系代数)
谷氨酸的
感觉系统
神经元
神经网络
皮质(解剖学)
大脑皮层
生物
计算机科学
谷氨酸受体
生物化学
受体
算法
作者
Hemanth Mohan,Xu An,Xinmeng Xu,Hideki Kondo,Shengli Zhao,Katherine SH Matho,Bor-Shuen Wang,Simon Musall,Partha P. Mitra,Z. Josh Huang
标识
DOI:10.1038/s41593-022-01244-w
摘要
The cellular basis of cerebral cortex functional architecture remains not well understood. A major challenge is to monitor and decipher neural network dynamics across broad cortical areas yet with projection-neuron-type resolution in real time during behavior. Combining genetic targeting and wide-field imaging, we monitored activity dynamics of subcortical-projecting (PTFezf2) and intratelencephalic-projecting (ITPlxnD1) types across dorsal cortex of mice during different brain states and behaviors. ITPlxnD1 and PTFezf2 neurons showed distinct activation patterns during wakeful resting, during spontaneous movements and upon sensory stimulation. Distinct ITPlxnD1 and PTFezf2 subnetworks were dynamically tuned to different sensorimotor components of a naturalistic feeding behavior, and optogenetic inhibition of ITsPlxnD1 and PTsFezf2 in subnetwork nodes disrupted distinct components of this behavior. Lastly, ITPlxnD1 and PTFezf2 projection patterns are consistent with their subnetwork activation patterns. Our results show that, in addition to the concept of columnar organization, dynamic areal and projection-neuron-type specific subnetworks are a key feature of cortical functional architecture linking microcircuit components with global brain networks.
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