胰腺癌
癌症
医学
癌症研究
内科学
肿瘤科
生物
生理学
病理
作者
Achinoam Isaacson,Debra Barki,Ruth Scherz‐Shouval
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2024-04-15
卷期号:84 (8): 1185-1187
标识
DOI:10.1158/0008-5472.can-24-0439
摘要
Abstract Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation of oncogenic mutations in cancer cells with age. However, fibroblasts are major constituents and key players in pancreatic cancer, and they too undergo age-related changes that may contribute to disease severity. In this issue of Cancer Research, Zabransky and colleagues set out to dissect the effect of age-related changes in pancreatic fibroblasts on pancreatic ductal adenocarcinoma growth and metastasis. They discovered that aged fibroblasts secrete GDF-15, which in turn activates AKT signaling and accelerates tumor progression. These findings provide a mechanistic role for aged fibroblasts in pancreatic cancer, underpinning the importance of normal physiologic processes in tumor progression. See related article by Zabransky et al., p. 1221
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