Tumor conspicuity enhancement-based segmentation model for liver tumor segmentation and RECIST diameter measurement in non-contrast CT images

Liver tumor segmentation (LiTS) accuracy on contrast-enhanced computed tomography (CECT) images is higher than that on non-contrast computed tomography (NCCT) images. However, CECT requires contrast medium and repeated scans to obtain multiphase enhanced CT images, which is time-consuming and cost-increasing. Therefore, despite the lower accuracy of LiTS on NCCT images, which still plays an irreplaceable role in some clinical settings, such as guided brachytherapy, ablation, or evaluation of patients with renal function damage. In this study, we intend to generate enhanced high-contrast pseudo-color CT (PCCT) images to improve the accuracy of LiTS and RECIST diameter measurement on NCCT images.To generate high-contrast CT liver tumor region images, an intensity-based tumor conspicuity enhancement (ITCE) model was first developed. In the ITCE model, a pseudo color conversion function from an intensity distribution of the tumor was established, and it was applied in NCCT to generate enhanced PCCT images. Additionally, we design a tumor conspicuity enhancement-based liver tumor segmentation (TCELiTS) model, which was applied to improve the segmentation of liver tumors on NCCT images. The TCELiTS model consists of three components: an image enhancement module based on the ITCE model, a segmentation module based on a deep convolutional neural network, and an attention loss module based on restricted activation. Segmentation performance was analyzed using the Dice similarity coefficient (DSC), sensitivity, specificity, and RECIST diameter error.To develop the deep learning model, 100 patients with histopathologically confirmed liver tumors (hepatocellular carcinoma, 64 patients; hepatic hemangioma, 36 patients) were randomly divided into a training set (75 patients) and an independent test set (25 patients). Compared with existing tumor automatic segmentation networks trained on CECT images (U-Net, nnU-Net, DeepLab-V3, Modified U-Net), the DSCs achieved on the enhanced PCCT images are both improved compared with those on NCCT images. We observe improvements of 0.696-0.713, 0.715 to 0.776, 0.748 to 0.788, and 0.733 to 0.799 in U-Net, nnU-Net, DeepLab-V3, and Modified U-Net, respectively, in terms of DSC values. In addition, an observer study including 5 doctors was conducted to compare the segmentation performance of enhanced PCCT images with that of NCCT images and showed that enhanced PCCT images are more advantageous for doctors to segment tumor regions. The results showed an accuracy improvement of approximately 3%-6%, but the time required to segment a single CT image was reduced by approximately 50 %.Experimental results show that the ITCE model can generate high-contrast enhanced PCCT images, especially in liver regions, and the TCELiTS model can improve LiTS accuracy in NCCT images.