Ineffectiveness of apremilast in moderate‐to‐severe pemphigus: A case series of three patients

Australasian Journal of DermatologyEarly View CLINICAL LETTER Ineffectiveness of apremilast in moderate-to-severe pemphigus: A case series of three patients Quanhong Zhang MM, Quanhong Zhang MM orcid.org/0009-0004-3796-0395 Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSearch for more papers by this authorLang Yu MM, Lang Yu MM Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China Jianghan University School of Medicine, Wuhan, ChinaSearch for more papers by this authorLi Wan MM, Li Wan MM Dermatology Hospital of Southern Medical University, Guangzhou, ChinaSearch for more papers by this authorLiuqing Chen MD, Corresponding Author Liuqing Chen MD [email protected] Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan, China Correspondence Jinbo Chen and Liuqing Chen, Department of Dermatology, Wuhan No. 1 Hospital, Zhongshan Avenue 215, Wuhan 430022, China. Email: [email protected] and [email protected]Search for more papers by this authorJinbo Chen MD, PhD, Corresponding Author Jinbo Chen MD, PhD [email protected] orcid.org/0000-0002-9665-8506 Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan, China Correspondence Jinbo Chen and Liuqing Chen, Department of Dermatology, Wuhan No. 1 Hospital, Zhongshan Avenue 215, Wuhan 430022, China. Email: [email protected] and [email protected]Search for more papers by this author Quanhong Zhang MM, Quanhong Zhang MM orcid.org/0009-0004-3796-0395 Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSearch for more papers by this authorLang Yu MM, Lang Yu MM Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China Jianghan University School of Medicine, Wuhan, ChinaSearch for more papers by this authorLi Wan MM, Li Wan MM Dermatology Hospital of Southern Medical University, Guangzhou, ChinaSearch for more papers by this authorLiuqing Chen MD, Corresponding Author Liuqing Chen MD [email protected] Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan, China Correspondence Jinbo Chen and Liuqing Chen, Department of Dermatology, Wuhan No. 1 Hospital, Zhongshan Avenue 215, Wuhan 430022, China. Email: [email protected] and [email protected]Search for more papers by this authorJinbo Chen MD, PhD, Corresponding Author Jinbo Chen MD, PhD [email protected] orcid.org/0000-0002-9665-8506 Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan, China Correspondence Jinbo Chen and Liuqing Chen, Department of Dermatology, Wuhan No. 1 Hospital, Zhongshan Avenue 215, Wuhan 430022, China. Email: [email protected] and [email protected]Search for more papers by this author First published: 24 May 2024 https://doi.org/10.1111/ajd.14312Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Meier K, Holstein J, Solimani F, Waschke J, Ghoreschi K. Case report: Apremilast for therapy-resistant pemphigus vulgaris. Front Immunol. 2020; 11:588315. https://doi.org/10.3389/fimmu.2020.588315 10.3389/fimmu.2020.588315 CASPubMedWeb of Science®Google Scholar 2Patra C, Foster K, Corley JE, Dimri M, Brady MF. Biochemistry, cAMP. StatPearls Treasure Island (FL); 2023. Google Scholar 3Ansari MA, Singh PK, Dar SA, Rai G, Akhter N, Pandhi D, et al. Deregulated phenotype of autoreactive Th17 and Treg clone cells in pemphigus vulgaris after in-vitro treatment with desmoglein antigen (Dsg-3). Immunobiology. 2023; 228:152340. https://doi.org/10.1016/j.imbio.2023.152340 10.1016/j.imbio.2023.152340 CASPubMedGoogle Scholar 4Stein Gold L, Papp K, Pariser D, Green L, Bhatia N, Sofen H, et al. Efficacy and safety of apremilast in patients with mild-to-moderate plaque psoriasis: results of a phase 3, multicenter, randomized, double-blind, placebo-controlled trial. 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