表观遗传学
免疫系统
免疫学
DNA甲基化
组蛋白
生物
炎症
生物标志物
核小体
液体活检
胎儿游离DNA
医学
癌症
基因表达
基因
遗传学
怀孕
胎儿
产前诊断
作者
Ilana Fox Fisher,Ruth Shemer,Yuval Dor
标识
DOI:10.1016/j.it.2023.03.005
摘要
Immune and inflammatory processes occurring within tissues are often undetectable by blood cell counts, standard circulating biomarkers, or imaging, representing an unmet biomedical need. Here, we outline recent advances indicating that liquid biopsies can broadly inform human immune system dynamics. Nucleosome-size fragments of cell-free DNA (cfDNA) released from dying cells into blood contain rich epigenetic information such as methylation, fragmentation, and histone mark patterns. This information allows to infer the cfDNA cell of origin, as well as pre-cell death gene expression patterns. We propose that the analysis of epigenetic features of immune cell-derived cfDNA can shed light on immune cell turnover dynamics in healthy people, and inform the study and diagnosis of cancer, local inflammation, infectious or autoimmune diseases, as well as responses to vaccination.
科研通智能强力驱动
Strongly Powered by AbleSci AI