光热治疗
纳米技术
荧光
光动力疗法
纳米颗粒
脱镁叶绿酸A
生物医学中的光声成像
黑色素瘤
化学
体内
纳米材料
癌症
材料科学
癌症研究
医学
有机化学
量子力学
光学
生物
生物技术
内科学
物理
作者
Prathamesh Patil,Nidhi Poddar,Nidhi Parihar,Seema Sen,Pallab Sinha Mahapatra,Suryanarayana Murty U,Deepak B. Pemmaraju
标识
DOI:10.1016/j.cej.2023.144110
摘要
Opto/light-responsive materials are a choice in modern-days due to their vital role in non-invasive cancer therapies and diagnostics. We propose a novel, near-infrared (NIR) light absorbing organometallic nanosystem for the multimodal theranostics against melanoma. More specifically, a fluorescent organic molecule, Pheophorbide-a (Ph-a) was loaded on the NIR light absorbing silver nanoparticles (AgNPs). The resulting formulation was referred to as PhAg NPs. The organic entity serves as a chemotherapeutic and imaging agent whereas the metallic system aid in the photothermal ablation of cancer cells. The PhAg NPs upon characterisation indicated a strong absorption in the NIR region and exhibited a robust photothermal profile upon exposure to the NIR light. The anti-cancer efficacy studies of the PhAg NPs were conducted in melanoma (in-vitro & in-vivo) models to understand the chemo/photothermal therapeutic effect. Our experimental results demonstrated a synergistic cytotoxic and tumor reduction effect due to the photothermal and chemotherapeutic potential of the PhAg NPs. Further photoacoustic (PA) and fluorescent imaging indicated that the PhAg NPs could serve as efficient non-invasive imaging probes due to their inherent NIR fluorescence properties. Overall, the PhAg NPs served as a unique organometallic system which had demonstrated its efficacy as a multimodal theranostic agent. Further in-depth understanding of the proposed organometallic nanoparticles (PhAg NPs) can be beneficial in their clinical translation against melanoma or similar tumors.
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