材料科学
伤口愈合
自愈
烧伤
生物医学工程
再生(生物学)
水泡
人造皮肤
分形
伤口敷料
复合材料
外科
医学
病理
数学分析
替代医学
细胞生物学
生物
数学
作者
Jinze Lan,Liqin Shi,Wuyi Xiao,Xiaobin Zhang,Shutao Wang
标识
DOI:10.1002/adma.202301765
摘要
Burn wounds pose great challenges for conventional dressings because massive exudates oversecreted from swollen tissues and blisters seriously delay wound healing. Herein, a self-pumping organohydrogel dressing with hydrophilic fractal microchannels is reported that can rapidly drain excessive exudates with ≈30 times enhancement in efficiency compared with the pure hydrogel, and effectively promote burn wound healing. A creaming-assistant emulsion interfacial polymerization approach is proposed to create the hydrophilic fractal hydrogel microchannels in the self-pumping organohydrogel through a dynamic floating-colliding-coalescing process of organogel precursor droplets. In a murine burn wound model, the rapid self-pumping organohydrogel dressings can markedly reduce dermal cavity by ≈42.5%, accelerate blood vessel regeneration by ≈6.6 times, and hair follicle regeneration by ≈13.5 times, compared with the commercial dressing (Tegaderm). This study paves an avenue for designing high-performance functional burn wound dressings.
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