Selenium-containing peptides attenuating Pb-induced memory impairment through microRNA-mediated signaling

lead acetate for 7 weeks. TSeMMM and SeMDPGQQ reversed Pb accumulation and oxidative stress indicators in the hippocampus, and the hippocampal neuron morphology was improved. Furthermore, the BDNF expression and Keap1/Nrf2 pathway were regulated to modulate the intrahippocampal antioxidant effect. There were 26 microRNAs aberrantly expressed by Pb administration, while treatment with high-dose TSeMMM and low-dose SeMDPGQQ restored 4 of them. This study will provide new insights into the mining of selenium-enriched functional factors.