表观遗传学
蛋白质组学
转录组
基因
计算生物学
生物信息学
生物
疾病
基因表达
医学
遗传学
内科学
作者
Jinlan Jiang,Siyun Liu,Huijuan Yang,Yingjie Lv,Ping Ma,Nansheng Chen,Ru Zhou
出处
期刊:Personalized Medicine
[Future Medicine]
日期:2023-03-01
卷期号:20 (2): 183-192
被引量:4
标识
DOI:10.2217/pme-2023-0020
摘要
The onset and progression of pulmonary arterial hypertension (PAH), a malignant disease, are associated with environmental and epigenetic factors. Recent advancements in transcriptomics and proteomics technology have provided new insights into PAH and identified novel gene targets involved in the development of the disease. Transcriptomic analysis has led to the discovery of possible novel pathways, such as miR-483 targeting several PAH-related genes and a mechanistic link between the increase in HERV-K mRNA and protein. Proteomic analysis has revealed crucial details, including the loss of SIRT3 activity and the significance of the CLIC4/Arf6 pathway in PAH pathogenesis. Gene profiles and protein interaction networks of PAH have been analyzed, clarifying the roles of differentially expressed genes or proteins in the occurrence and development of PAH. This article discusses these recent advances.
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