The crosstalk between cellular survival pressures and N6-methyladenosine modification in hepatocellular carcinoma

BACKGROUND: A axis in HCC diagnosis and treatment. DATA SOURCES: A literature search was conducted in PubMed, MEDLINE, and Web of Science for relevant articles published up to April 2024. The keywords used for the search included hepatocellular carcinoma, cellular survival, survival pressure, N6-methyladenosine, tumor microenvironment, stress response, and hypoxia. RESULTS: A RNA methylation mechanisms to develop novel, and more effective treatments for HCC. CONCLUSIONS: A RNA methylation emerges as a complex regulatory network that influences HCC pathogenesis and progression.