医学
放射治疗
倾向得分匹配
鼻咽癌
总体生存率
生活质量(医疗保健)
队列
癌
外科
内科学
放射科
肿瘤科
护理部
作者
Rui You,Xiong Zou,Yi Hua,Fei Han,Li Li,Chong Zhao,Ming Hong,Ming Yuan Chen
标识
DOI:10.1016/j.radonc.2015.04.024
摘要
Salvage ENPG and IMRT are more effective treatments for rNPC than traditional 2-dimensional radiotherapy. However, compared with IMRT, the benefits of ENPG have not yet been clearly described.We defined a resectable area in which the disease could be radically removed using ENPG and our imaging specialists selected eligible patients with tumors confined to this resectable area from a database of rNPC patients. Using propensity scores to adjust for some potential prognostic factors, a well-balanced cohort of 144 limited rNPC patients was created by matching each patient who underwent ENPG (study group) with one who underwent IMRT (control group). Morbidity, long-term oncological results, treatment-related complications, medical costs, and quality of life were compared.Compared with IMRT, ENPG was associated with a relatively good overall survival (5-year OS, 77.1% vs 55.5%, P=.003), QOL conservation (mean global health status score, 57.6 vs 29.8, P<.001), and significant decreases in post-treatment complications (12.5% vs 65.3%, P<.001), medical costs (23 645.90 vs 118 122.53 Yuan, P<.001)≈(€2371.71 vs 11,847.80, P<.001).Salvage ENPG may be more effective for maximizing survival and QOL benefits and minimizing treatment-related complications and medical costs for limited rNPC patients, as compared with IMRT.
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