尿素
硫脲
化学
受体酪氨酸激酶
酪氨酸激酶
激酶
合理设计
生物化学
微管蛋白
组合化学
药理学
受体
微管
生物
细胞生物学
有机化学
遗传学
作者
Huan‐Qiu Li,Peng‐Cheng Lv,Tao Yan,Hai‐Liang Zhu
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2009-05-01
卷期号:9 (4): 471-480
被引量:123
标识
DOI:10.2174/1871520610909040471
摘要
Within the past ten years, a huge volume of research on the synthesis, structure-activity relationships (SAR), and anticancer activities of the urea derivatives was reported. Many aromatic urea derivatives such as N-phenyl-N'-(2-chloroethyl)ureas (CEUs) and benzoylureas (BUs) show good anticancer activity, and these compounds have mainly been proved to be tubulin ligands that inhibit the polymerization of tubulin. Heterocyclic urea derivatives play an important role in anticancer agents because of their good inhibitory activity against receptor tyrosine kinases (RTKs), raf kinases, protein tyrosine kinases (PTKs), and NADH oxidase, which play critical roles in many aspects of tumorigenesis. Thiourea derivatives are also of wide interest because of their diverse anticancer activity against various leukemias and solid tumors. In this review, the anticancer activity of the urea derivatives mentioned above is summarized in detail. It is hoped that increasing knowledge of the SAR and cellular processes underlying the antitumor-activity of urea derivatives will be beneficial to the rational design of new generation of urea anticancer drugs.
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