衰老
间充质干细胞
DNA损伤
细胞凋亡
细胞生物学
间质细胞
干细胞
生物
DNA修复
程序性细胞死亡
细胞分化
癌症研究
DNA
端粒
遗传学
基因
作者
Behnaz Banimohamad-Shotorbani,Houman Kahroba,Hadi Sadeghzadeh,David M. Wilson,Hamid Maadi,Nasser Samadi,Mohammad Saeid Hejazi,Hekmat Farajpour,Behzad Nemati Onari,Mohammad Reza Sadeghi
标识
DOI:10.1016/j.arr.2020.101125
摘要
Mesenchymal stromal cells (MSCs) are heterogeneous and contain several populations, including stem cells. MSCs' secretome has the ability to induce proliferation, differentiation, chemo-attraction, anti-apoptosis, and immunomodulation activities in stem cells. Moreover, these cells recognize tissue damage caused by drugs, radiation (e.g., Ultraviolet, infra-red) and oxidative stress, and respond in two ways: either MSCs differentiate into particular cell lineages to preserve tissue homeostasis, or they release a regenerative secretome to activate tissue repairing mechanisms. The maintenance of MSCs in quiescence can increase the incidence and accumulation of various forms of genomic modifications, particularly upon environmental insults. Thus, dysregulated DNA repair pathways can predispose MSCs to senescence or apoptosis, reducing their stemness and self-renewal properties. For instance, DNA damage can impair telomere replication, activating DNA damage checkpoints to maintain MSC function. In this review, we aim to summarize the role of DNA damage and associated repair responses in MSC senescence, differentiation and programmed cell death.
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