辅酶Q10
医学
氧化应激
糖尿病肾病
糖基化
糖尿病
硫辛酸
抗氧化剂
白藜芦醇
活性氧
一氧化氮
内科学
肾病
内分泌学
胰岛素抵抗
药理学
生物化学
化学
作者
Francisco Gerardo Yanowsky-Escatell,Jorge Andrade‐Sierra,Leonardo Pazarín–Villaseñor,Christian Santana-Arciniega,Eduardo de Jesús Torres-Vazquez,Jonathan S. Chávez-Íñiguez,Miguel Ángel Zambrano-Velarde,Francisco Martín Preciado-Figueroa
摘要
Diabetic nephropathy (ND) is the leading cause of end-stage renal disease and oxidative stress (OS) has been recognized as a key factor in the pathogenesis and progression. Hyperglycemia, reactive oxygen species, advanced glycation end products, arterial pressure, insulin resistance, decrease in nitric oxide, inflammatory markers, and cytokines, among others; are involved in the presence of OS on ND. This revision focus on diverse studies in experimental and human models with diabetes and DN that has been demonstrated beneficial effects of different dietary antioxidant as resveratrol, curcumin, selenium, soy, catechins, α-lipoic acid, coenzyme Q10, omega-3 fatty acids, zinc, vitamins E and C, on OS and the capacity for antioxidant response. Therefore, this interventions could have a positive clinical impact on DN.
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