腺苷
炎症
腺苷受体
神经科学
免疫系统
促炎细胞因子
受体
分辨率(逻辑)
免疫学
医学
药理学
生物
计算机科学
内分泌学
内科学
兴奋剂
人工智能
作者
Luca Antonioli,Pál Pacher,György Haskó
标识
DOI:10.1016/j.tips.2021.10.010
摘要
Resolution of inflammation requires proresolving molecular pathways triggered as part of the host response during the inflammatory phase. Adenosine and its receptors, which are collectively called the adenosine system, shape inflammatory cell activity during the active phase of inflammation, leading these immune cells toward a functional repolarization, thus contributing to the onset of resolution. Strategies based on the resolution of inflammation have shaped a new area of pharmacology referred to as 'resolution pharmacology' and in this regard, the adenosine system represents an interesting target to design novel pharmacological tools to 'resolve' the inflammatory process. In this review, we outline the role of the adenosine system in driving the events required for an effective transition from the proinflammatory phase to the onset and establishment of resolution.
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