多巴胺能
MPTP公司
增食欲素
兴奋性突触后电位
神经科学
帕金森病
多巴胺能途径
多巴胺
黑质
医学
内科学
内分泌学
受体
生物
抑制性突触后电位
神经肽
疾病
作者
Kang Bian,Cui Liu,Mengying Wang,Yan Xue,Lei Chen
标识
DOI:10.1016/j.neulet.2021.136291
摘要
The study aimed to investigate the effects of orexin-B in Parkinson's disease. The present study showed that orexin-B exerted marked excitatory effects via orexin-2 receptor on the nigral dopaminergic neurons in MPTP parkinsonian mice, while blocking orexin-2 receptor decreased the firing rate of dopaminergic neurons significantly. Furthermore, intracerebroventricular application of orexin-B relieved the degeneration of dopaminergic neurons, increased the general spontaneous activity and alleviated motor coordination in MPTP parkinsonian mice. The present study suggests that orexin-B could exert protective effects on dopaminergic neurons and improve motor disorders in parkinsonian mice. Such protective effects of orexin-B on Parkinson's disease may be partially attributed to the excitatory effects on the nigral dopaminergic neurons.
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