VITAMIN B12 AND HOMOCYSTEINE LEVELS IN PATIENTS WITH NAFLD: A SYSTEMATIC REVIEW AND METANALYSIS

医学 维生素B12 内科学 同型半胱氨酸 胃肠病学 非酒精性脂肪肝 脂肪肝 疾病
作者
Débora Silva Costa,Marina P Guahnon,Fernanda Braga Seganfredo,Letícia Pereira Pinto,Cristiane Valle Tovo,Sabrina Alves Fernandes
出处
期刊:Arquivos De Gastroenterologia [SciELO]
卷期号:58 (2): 234-239 被引量:14
标识
DOI:10.1590/s0004-2803.202100000-42
摘要

ABSTRACT BACKGROUND: The vitamin B12 absorption can be affected in patients with nonalcoholic fatty liver disease (NAFLD), and low serum vitamin B12 levels has been related to the high homocysteine (HCY) levels and to the degree of NAFLD. OBJECTIVE: To carry out a systematic review and metanalysis of serum vitamin B12 and HCY levels in patients with NAFLD. METHODS: Original studies including serum vitamin B12 and HCY levels in humans with NAFLD were included. The searches were performed in four databases. RESULTS: 159 studies were identified, and after excluding the duplicates and non-eligible titles, eight original articles were included. Six out of eight showed higher B12 levels in NAFLD patients (404.9±136.2 pg/mL in relation to controls 353.91±117.3 pg/mL). Seven of the eight studies also showed higher HCY levels in NAFLD patients (14.2±3.44 umol/L in relation to controls 11.05±3.6 umol/L). The results for serum vitamin B12 and HCY levels were submitted to metanalysis, showing no difference in the vitamin B12 levels between patients with NAFLD and controls. However, the levels of Hcy were higher in NAFLD patients than in controls. CONCLUSION: There was no relashionship between the vitamin B12 levels and NAFLD. The levels of HCY were significantly higher in patients with NAFLD, suggesting this could be a potential marker for liver damage.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
4秒前
共享精神应助小吴搞科研采纳,获得10
4秒前
顾矜应助你好采纳,获得10
4秒前
gakiki完成签到 ,获得积分10
9秒前
直率的柚子完成签到,获得积分10
10秒前
Vito发布了新的文献求助10
10秒前
13秒前
微微为发布了新的文献求助30
15秒前
18秒前
yu发布了新的文献求助10
18秒前
20秒前
Leonardi应助西河采纳,获得10
20秒前
情怀应助永康采纳,获得10
21秒前
mobo完成签到,获得积分10
21秒前
徐锦涛发布了新的文献求助10
22秒前
22秒前
25秒前
桐桐应助ahhh采纳,获得10
25秒前
26秒前
FashionBoy应助清爽的洋葱采纳,获得10
27秒前
28秒前
29秒前
30秒前
菜鸡完成签到,获得积分10
30秒前
真实的俊驰完成签到,获得积分10
31秒前
Harbour-Y完成签到 ,获得积分10
31秒前
哇卡哇卡完成签到,获得积分10
32秒前
你好发布了新的文献求助10
33秒前
健康的水杯完成签到 ,获得积分10
33秒前
哇卡哇卡发布了新的文献求助10
35秒前
情怀应助向日繁花采纳,获得10
36秒前
yu完成签到,获得积分10
36秒前
monica完成签到 ,获得积分10
40秒前
枫叶-ZqqC发布了新的文献求助10
42秒前
45秒前
Inasne发布了新的文献求助10
46秒前
47秒前
ahhh发布了新的文献求助10
51秒前
情怀应助徐锦涛采纳,获得10
51秒前
Orange应助Neunsonne采纳,获得10
52秒前
高分求助中
Teaching Social and Emotional Learning in Physical Education 900
Plesiosaur extinction cycles; events that mark the beginning, middle and end of the Cretaceous 800
Recherches Ethnographiques sue les Yao dans la Chine du Sud 500
Two-sample Mendelian randomization analysis reveals causal relationships between blood lipids and venous thromboembolism 500
Chinese-English Translation Lexicon Version 3.0 500
[Lambert-Eaton syndrome without calcium channel autoantibodies] 440
Wisdom, Gods and Literature Studies in Assyriology in Honour of W. G. Lambert 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2389736
求助须知:如何正确求助?哪些是违规求助? 2095729
关于积分的说明 5278745
捐赠科研通 1822898
什么是DOI,文献DOI怎么找? 909283
版权声明 559593
科研通“疑难数据库(出版商)”最低求助积分说明 485920