生物粘附
奥斯特瓦尔德成熟
纳米技术
纳米颗粒
药物输送
材料科学
生物利用度
涂层
药品
化学工程
药理学
医学
工程类
作者
Guizhi Shen,Ronge Xing,Ning Zhang,Chengjun Chen,Guanghui Ma,Xuehai Yan
出处
期刊:ACS Nano
[American Chemical Society]
日期:2016-05-27
卷期号:10 (6): 5720-5729
被引量:162
标识
DOI:10.1021/acsnano.5b07276
摘要
The majority of anticancer drugs are poorly water-soluble and thus suffer from rather low bioavailability. Although a variety of delivery carriers have been developed for bioavailability improvement, they are severely limited by low drug loading and undesired side effects. The optimum delivery vehicle would be a biocompatible and biodegradable drug nanoparticle of uniform size with a thin but stable shell, making it soluble, preventing aggregation and enabling targeting. Here, we present a general strategy for the rational design of hydrophobic drug nanoparticles with high drug loading by means of interfacial cohesion and supramolecular assembly of bioadhesive species. We demonstrate that the pathway is capable of effectively suppressing and retarding Ostwald ripening, providing drug nanoparticles with small and uniform size and long-term colloidal stability. The final complex drug nanoparticles provide higher tumor accumulation, negligible toxicity, and enhanced antitumor activity, superior to commercial formulations. Our findings demonstrate that local, on-demand coating of hydrophobic nanoparticles is achievable through cooperation and compromise of interfacial adhesion and assembly.
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