环糊精
异氰酸酯
对映体
化学
介孔二氧化硅
非对映体
高效液相色谱法
共价键
有机化学
二氯苯
聚合
介孔材料
化学工程
催化作用
聚合物
聚氨酯
工程类
作者
Shuai Lv,Chuan-Bao Ma,Hailin Cong,Youqing Shen,Bing Yu
标识
DOI:10.1016/j.seppur.2022.121147
摘要
β-Cyclodextrin (β-CD) has a unique three-dimensional structure and chemical properties, and has a strong chiral separation ability. In this study, we linked 3,5-dichlorobenzene isocyanate to β-cyclodextrin and named this newly synthesized molecule β-CD-DCIPI. 3,5-Dimethylbenzene isocyanate was attached to β-cyclodextrin and named β-CD-DPIC. A modified polymerization-induced colloidal aggregation (PICA) method and self-made silica sol were used to synthesize mesoporous silica microspheres with a particle size of 2.38 μm-5.51 μm. A green non-toxic diazoresin (DR) is used as a coupling agent, which is connected to the surface of silica microspheres through electrostatic interaction. After ultraviolet light irradiation, ionic bonds are transformed into covalent bonds, and a new chiral stationary phase with chiral separation properties (β[email protected]2 and β[email protected]2) is constructed. This article first characterizes the properties of mesoporous silica microspheres and β[email protected]2 and β[email protected]2. Through reversed-phase high-performance liquid chromatography (RP-HPLC), the separation performance of two new chiral stationary phases in chiral compounds was explored and compared, and five chiral enantiomers were effectively separated.
科研通智能强力驱动
Strongly Powered by AbleSci AI