区域选择性
化学
铑
卡宾
催化作用
立体化学
氧化还原
药物化学
组合化学
有机化学
作者
Fan Wu,Lin Xiao,Hongmei Xie,Shaoyong Chen,Jia‐Lin Song,Yi-Chuan Zheng,Yanzhi Liu,Shang‐Shi Zhang
摘要
Herein, we report a Rh(III)-catalyzed C4-selective activation of indoles by using iodonium ylides as carbene precursors. This protocol proceeded under redox neutral reaction conditions and provided important coupling products with good tolerance of functional groups and high yields. In addition, one-pot synthesis and scale-up and mechanistic studies were also conducted.
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