聚合酶
核酸内切酶
病毒
病毒学
RNA聚合酶
甲型流感病毒
酶
生物
作者
Yixin Ren,Yutao Chen,Shuang Cao
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2022-02-25
标识
DOI:10.4155/fmc-2021-0264
摘要
Influenza is a type of acute respiratory virus infection caused by the influenza virus that occurs in epidemics worldwide every year. Due to the increasing incidence of influenza virus resistance to existing drugs, researchers are looking for novel antiviral drugs with new mechanisms. The endonuclease activity of polymerase acidic protein is essential in the process of influenza virus reproduction, and inhibiting it could prevent the virus from replicating. There are relatively few drugs that act on this protein, and only baloxavir marboxil has been approved for clinical use. In this article, the structure and function of influenza virus polymerase acidic protein endonuclease, mechanism of action of polymerase acidic endonuclease inhibitors and the research progress of inhibitors are reviewed.
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