化学
一氧化氮
脐静脉
抗菌剂
体内
生物物理学
体外
伤口愈合
血管生成
金黄色葡萄球菌
香豆素
生物化学
药理学
细胞生物学
细菌
癌症研究
免疫学
有机化学
医学
遗传学
生物技术
生物
作者
Yue Xu,Hua Li,Shiwen Xu,Xian Liu,Jingjing Lin,Haiyan Chen,Zhenwei Yuan
标识
DOI:10.1021/acs.jmedchem.1c01591
摘要
Nitric oxide (NO) has an important class of endogenous diatomic molecules that play a key regulatory role in many physiological and biochemical processes. However, the type of nitrosamine NO donor stimulated by light has many advantages compared to the conventional NO donors such as diazeniumdiolates and S-nitrosothiols compounds, including easy synthesis, good stability, and controllable release. In addition, NO release can be regulated by light induction with a built-in calibration mechanism fluorescence. Here, we report that the migration and proliferation of human umbilical vein vascular endothelial cells could be accelerated by the light-triggered NO donors, leading to the angiogenesis. Meanwhile, the screened NO donor 3a with Levofloxacin (Lev) showed synergistic effects to eradicate Methicillin-resistant Staphylococcus aureus (MRSA) biofilms in vitro and treat bacteria-infected wound in vivo.
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