部分
血红素
二茂铁
氧化还原
适体
化学
G-四倍体
胶体金
组合化学
信号(编程语言)
生物传感器
选择性
光化学
电极
材料科学
纳米颗粒
无机化学
纳米技术
电化学
血红素
立体化学
有机化学
催化作用
生物
物理化学
计算机科学
遗传学
DNA
程序设计语言
生物化学
酶
作者
Ying Liu,Fengting Chen,Zhenzhu Luan,Xiaoru Zhang
标识
DOI:10.1016/j.bios.2018.07.068
摘要
Novel cathodic photoelectrochemical (PEC) aptasensors for sensitive and selective determination of thrombin and Pb2+ were developed based on a new dual-signal amplification strategy. The presence of gold nanoparticles (AuNPs) could quench the PEC signal of bismuth oxyiodide (BiOI). At the same time, the redox moiety G-quadruplex/hemin or ferrocene (Fc) was found to enhance the PEC signal of BiOI. So, in the presence of thrombin or Pb2+, the interaction between target and the aptamer resulted in the releasement of the AuNPs, as well as shorter distance between the redox moiety and the electrode surface. Hence dual-enhanced cathodic PEC biosensor strategy was realized. Under the optimized conditions, the detection limits of thrombin and Pb2+ were 17.3 fM and 3.16 pM, respectively with good selectivity. At the same time, the PEC performance of redox moiety G-quadruplex/hemin and Fc was compared.
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