过氧化氢
阿霉素
化学
肿瘤微环境
癌细胞
内化
癌症研究
细胞毒性
癌症
化疗
生物化学
肿瘤细胞
细胞
医学
体外
内科学
外科
作者
Miao Su,Yueqiang Zhu,Junbin Chen,Beibei Zhang,Chunyang Sun,Meiwan Chen,Xianzhu Yang
标识
DOI:10.1016/j.cej.2022.134926
摘要
As an interesting alternative to traditional cancer therapies, chemodynamic therapy (CDT) can kill cancer cells via the conversion of endogenous hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (⋅OH). However, the slow release of catalyst ions and insufficient H2O2 levels severely limit the performance of CDT. To address these issues, we explored the doxorubicin (DOX)-loaded manganese-alginate nanogel DOX@Mn-Alg with self-supplying H2O2 capability by using a microfluidic chip. After internalization into tumor cells, DOX@Mn-Alg quickly releases DOX in a pH-responsive manner. The released DOX can not only kill tumor cells directly but also improve Mn2+-mediated CDT by supplying H2O2 within the tumor cells. As a result, the DOX@Mn-Alg showed synergetic antitumor activity without causing distinct systemic toxicity, and also achieved T1-weighted magnetic resonance imaging (MRI) enhancement for cancer diagnosis. Moreover, DOX@Mn-Alg treatment can promote DC maturation and increase tumor infiltration of CD8+ T cells. It is believed that these Mn2+-chelating nanogels with the ability to self-supply H2O2 can provide additional strategy for synergetic CDT therapy and also exhibit a promising potential for cancer immunotherapy.
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