病毒性表皮
生物
粘液瘤病毒
溶瘤病毒
曼氏血吸虫
病毒学
扁虫
吡喹酮
病毒
血吸虫
血吸虫病
免疫学
蠕虫
动物
作者
Masmudur M. Rahman,Grant McFadden,Gordon Ruthel,De’Broski R. Herbert,Bruce D. Freedman,Robert M. Greenberg,Swarna Bais
标识
DOI:10.1016/j.exppara.2022.108263
摘要
Schistosomiasis is a devastating disease caused by parasitic flatworms of the genus Schistosoma. Praziquantel (PZQ), the current treatment of choice, is ineffective against immature worms and cannot prevent reinfection. The continued reliance on a single drug for treatment increases the risk of the development of PZQ-resistant parasites. Reports of PZQ insusceptibility lends urgency to the need for new therapeutics. Here, we report that Myxoma virus (MYXV), an oncolytic pox virus which is non-pathogenic in all mammals except leporids, infects and replicates in S. mansoni schistosomula, juveniles, and adult male and female worms. MYXV infection results in the shredding of the tegument and reduced egg production in vitro, identifying MYXV as the first viral pathogen of schistosomes. MYXV is currently in preclinical studies to manage multiple human cancers, supporting its use in human therapeutics. Our findings raise the exciting possibility that MYXV virus represents a novel and safe class of potential anthelmintic therapeutics.
科研通智能强力驱动
Strongly Powered by AbleSci AI