紫杉醇
共轭体系
靶向给药
药物输送
肽
HER2/东北
纳米颗粒
化学
纳米技术
细胞毒性
氧化铁纳米粒子
靶向治疗
配体(生物化学)
乳腺癌
材料科学
癌症
体外
生物化学
受体
聚合物
医学
有机化学
内科学
作者
Qingxin Mu,Forrest M. Kievit,Rajeev J. Kant,Guorong Lin,Mike Jeon,Miqin Zhang
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2015-01-01
卷期号:7 (43): 18010-18014
被引量:75
摘要
Nanoparticles (NPs) for targeted therapy are required to have appropriate size, stability, drug loading and release profiles, and efficient targeting ligands. However, many of the existing NPs such as albumin, liposomes, polymers, gold NPs, etc. encounter size limit, toxicity and stability issues when loaded with drugs, fluorophores, and targeting ligands. Furthermore, antibodies are bulky and this can greatly affect the physicochemical properties of the NPs, whereas many small molecule-based targeting ligands lack specificity. Here, we report the utilization of biocompatible, biodegradable, small (∼30 nm) and stable iron oxide NPs (IONPs) for targeted delivery of paclitaxel (PTX) to HER2/neu positive breast cancer cells using an anti-HER2/neu peptide (AHNP) targeting ligand. We demonstrate the uniform size and high stability of these NPs in biological medium, their effective tumour targeting in live mice, as well as their efficient cellular targeting and selective killing in human HER2/neu-positive breast cancer cells.
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