A genetic portrait of metastatic seeds in lung adenocarcinoma

Patients with lung adenocarcinomas (LUAD) frequently develop metastasis. In this issue of Cancer Cell, Lengel et al. perform a comprehensive analysis of metastasis patterns in 2,532 LUAD samples to identify clinicopathologic and genomic features of LUAD tumors associated with metastatic development, burden, and organotropism. Patients with lung adenocarcinomas (LUAD) frequently develop metastasis. In this issue of Cancer Cell, Lengel et al. perform a comprehensive analysis of metastasis patterns in 2,532 LUAD samples to identify clinicopathologic and genomic features of LUAD tumors associated with metastatic development, burden, and organotropism. Genomic mapping of metastatic organotropism in lung adenocarcinomaLengel et al.Cancer CellApril 20, 2023In BriefLengel et al. identify clinicopathological and genomic features of lung adenocarcinoma associated with the development of metastasis, metastatic burden, organotropism, and metastasis-free survival. The findings illustrate that metastatic tumors have increased chromosomal instability, share the majority of driver mutations with the primary tumor, and rarely develop new clinically targetable alterations. Full-Text PDF