A Photon‐Driven Unimolecular Immunostimulant for Self‐Amplified Pyroptosis and cGAS‐STING Pathway by Destroying the Pyroptosis Checkpoint

, but also enhances the cGAS-STING innate immune pathway by releasing mitochondrial DNA. More importantly, the initial lysosomal damage impairs protective cellular autophagy, destroying the pyroptosis checkpoint and thus preventing the clearance of damaged mitochondria and amplifying immune responses, ultimately boosting immunotherapy. This strategy effectively treats primary tumors and inhibits metastatic growth, offering a new paradigm for photoimmunotherapy.