葛根
脂质代谢
抗性淀粉
肠道菌群
淀粉
新陈代谢
食品科学
洛巴塔
生物
化学
内分泌学
生物化学
医学
替代医学
病理
作者
Meiying Lai,Na Li,Quancen Li,Xiaodong Ge,Zifeng Huang,Fujie Chen,Bin Liu,Feng Zeng
标识
DOI:10.1002/star.202300123
摘要
Abstract Pueraria lobata resistant starch (PLRS) is prepared by modifying Pueraria lobata starch with pullulanase, and the PLRS modulate lipid metabolism disorders and gut microbiota structure are hypothesized in high‐fat diet (HFD) mice. The results reveal that the PLRS can alleviate lipid metabolism disorders by significantly upregulating the abundance of Akkermansia , Lactobacillus , Blautia , and Dubosiella , but markedly downregulating Staphylococcus in HFD mice. The PLRS may decrease the gain of weight, biochemical index, ameliorate hepatic impairment, and histopathological. Molecular mechanisms have elucidated that the PLRS may exert reducing fat accumulation and stabilize the gut microbiota effects through the modulation of the fatty acid metabolic signaling pathway and the PPAR signaling pathway. Therefore, these results suggest that this prebiotic carbohydrate may regulate lipid metabolism and gut microbiota in HFD mice and can be used to prepare healthy lipid‐lowering functional foods to attenuate obesity problems.
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