Overlap of Esophageal Disorders of Gut-Brain Interactions and Gastroesophageal Reflux Disease Is Highly Prevalent in Patients With Refractory Reflux Symptoms

E-DGBIs are highly prevalent in patients with proven GERD and refractory reflux symptoms. Studies with outcome data are needed to determine whether patients with overlapping E-DGBIs and GERD should be identified with pH-impedance monitoring on PPI therapy before an interventional treatment option is considered.