炎症
造血
恶性肿瘤
疾病
髓样
免疫学
祖细胞
体细胞
医学
全身炎症
生物
生物信息学
干细胞
内科学
遗传学
基因
作者
Daniel I. Nathan,Max L. Dougherty,Manasa Bhatta,John Mascarenhas,Bridget K. Marcellino
标识
DOI:10.1016/j.critrevonc.2023.104187
摘要
Clonal hematopoiesis (CH) is defined by the presence of somatic mutations in hematopoietic stem and progenitor cells (HSPC). CH is associated primarily with advancing age and confers an elevated risk of progression to overt hematologic malignancy and cardiovascular disease. Increasingly, CH is associated with a wide range of diseases driven by, and sequelae of, inflammation. Accordingly, there is great interest in better understanding the pathophysiologic and clinical relationship between CH, aging, and disease. Both observational and experimental findings support the concept that CH is a potential common denominator in the inflammatory outcomes of aging. However, there is also evidence that local and systemic inflammatory states promote the growth and select for CH clones. In this review, we aim to provide an up-to-date summary of the nature of the relationship between inflammation and CH, which is central to unlocking potential therapeutic opportunities to prevent progression to myeloid malignancy.
科研通智能强力驱动
Strongly Powered by AbleSci AI