胰高血糖素
葡萄糖稳态
胰岛素
低血糖
激素
透皮
血糖性
苯硼酸
内分泌学
内科学
胰岛素释放
医学
化学
糖尿病
药理学
1型糖尿病
生物化学
胰岛素抵抗
催化作用
作者
Changwei Yang,Tao Sheng,Wenhui Hou,Juan Zhang,Li Cheng,Hao Wang,Wei Liu,Shiqi Wang,Xinmin Yu,Yuqi Zhang,Jicheng Yu,Zhen Gu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-11-30
卷期号:8 (48)
被引量:51
标识
DOI:10.1126/sciadv.add3197
摘要
Insulin and glucagon secreted from the pancreas with dynamic balance play a vital role in regulating blood glucose levels. Although distinct glucose-responsive insulin delivery systems have been developed, the lack of a self-regulated glucagon release module limits their clinical applications due to the potential risk of hypoglycemia. Here, we describe a transdermal polymeric microneedle patch for glucose-responsive closed-loop insulin and glucagon delivery to achieve glycemic regulation with minimized risk of hypoglycemia. The glucose-responsive phenylboronic acid units can bind to glucose to reversibly shift the net charge (from positive to negative) of the entire polymeric matrix within microneedles. Therefore, the release ratio of the negatively charged insulin and the positively charged glucagon analog from the patch can be dynamically tuned upon the fluctuation of blood glucose levels to realize glycemic homeostasis. In both chemically induced type 1 diabetic mouse and minipig models, this glucose-responsive dual-hormone microneedle patch demonstrated tight long-term regulation in blood glucose levels (>24 hours in minipigs).
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