表观基因组
表观遗传学
DNA甲基化
前列腺癌
生物
表观遗传学
计算生物学
转录组
DNA
癌症
遗传学
生物信息学
基因
基因表达
作者
Anjui Wu,Gerhardt Attard
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2022-11-02
卷期号:82 (21): 3880-3881
标识
DOI:10.1158/0008-5472.can-22-2750
摘要
Abstract Cancer epigenome profiling such as DNA methylation (5mC) and DNA hydroxymethylation (5hmC) is emerging as a sensitive approach for cancer detection and risk stratification. 5mC modification has been widely described in many cancer types including prostate cancer; however, the 5hmC landscape is yet to be explored. In this issue of Cancer Research, Sjöström and colleagues have comprehensively incorporated genomic, transcriptomic, and epigenomic, including 5hmC, data to interrogate the molecular evolution of prostate cancer. See related article by Sjöström et al., p. 3888
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