光动力疗法
单线态氧
卟啉
过氧化氢
活性氧
化学
肿瘤微环境
激进的
光化学
癌症研究
材料科学
生物物理学
氧气
生物化学
医学
肿瘤细胞
有机化学
生物
作者
Xiaohui Zhu,Min Wang,Haihui Wang,Yi-hang Ding,Yongfei Liu,Zhangcheng Fu,Danying Lin,Chunhua Lü,Xian-kun Tu
出处
期刊:Small
[Wiley]
日期:2022-11-04
卷期号:18 (52)
被引量:14
标识
DOI:10.1002/smll.202204951
摘要
Photodynamic therapy (PDT) has been showing great potential in cancer treatment. However, the efficacy of PDT is always limited by the intrinsic hypoxic tumor microenvironment (TME) and the low accumulation efficiency of photosensitizers in tumors. To address the issue, a multifunctional hollow multilayer nanoplatform (H-MnO2 @TPyP@Bro) comprising manganese dioxide, porphyrin (TPyP) and bromelain (Bro), is developed for enhanced photodynamic therapy. MnO2 catalyzes the intracellular hydrogen peroxide (H2 O2 ) to produce oxygen (O2 ), reversing the hypoxic TME in vivo. The generated O2 is converted into singlet oxygen (1 O2 ) by the TPyP shell under near-infrared light, which can inhibit tumor proliferation. Meanwhile, the Bro can digest collagen in the extracellular matrix around the tumor, and can promote the accumulation of H-MnO2 @TPyP@Bro in the deeper tumor tissue, further improving the therapeutic effect of PDT. In addition, MnO2 can react with the overexpressed glutathione in TME to release Mn2+ . Consequently, Mn2+ not only induces chemo-dynamic therapy based on Fenton reaction by converting H2 O2 into hydroxyl radicals, but also activates the Mn2+ -based magnetic resonance imaging. Therefore, the developed H-MnO2 @TPyP@Bro nanoplatform can effectively modulate the unfavorable TME and overcome the limitations of conventional PDT for cancer diagnostic and therapeutic.
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