生物
基因
有机体
果蝇属(亚属)
进化生物学
模式生物
遗传学
功能(生物学)
作者
Sidi Chen,Yong E. Zhang,Manyuan Long
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2010-12-17
卷期号:330 (6011): 1682-1685
被引量:263
标识
DOI:10.1126/science.1196380
摘要
To investigate the origin and evolution of essential genes, we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interference showed that 30% of newly arisen genes are essential for viability. The proportion of genes that are essential is similar in every evolutionary age group that we examined. Under constitutive silencing of these young essential genes, lethality was high in the pupal stage and also found in the larval stages. Lethality was attributed to diverse cellular and developmental defects, such as organ formation and patterning defects. These data suggest that new genes frequently and rapidly evolve essential functions and participate in development.
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