胆碱能的
胆碱乙酰转移酶
囊泡乙酰胆碱转运体
胆碱能神经元
乙酰胆碱
骨形态发生蛋白
中枢神经系统
生物
胆碱能纤维
神经科学
细胞生物学
表型
内科学
内分泌学
基因
遗传学
医学
作者
Ignacio Lopez-Coviella,Brygida Berse,Raul Krauss,R. Scott Thies,Jan Krzysztof Blusztajn
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2000-07-14
卷期号:289 (5477): 313-316
被引量:216
标识
DOI:10.1126/science.289.5477.313
摘要
Bone morphogenetic proteins (BMPs) have multiple functions in the developing nervous system. A member of this family, BMP-9, was found to be highly expressed in the embryonic mouse septum and spinal cord, indicating a possible role in regulating the cholinergic phenotype. In cultured neurons, BMP-9 directly induced the expression of the cholinergic gene locus encoding choline acetyltransferase and the vesicular acetylcholine transporter and up-regulated acetylcholine synthesis. The effect was reversed upon withdrawal of BMP-9. Intracerebroventricular injection of BMP-9 increased acetylcholine levels in vivo. Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons.
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