纺神星
医学
长寿
锡尔图因
疾病
骨质疏松症
内分泌系统
激素替代疗法(女性对男性)
糖尿病
早衰
癌症
成功老龄化
生物信息学
老年学
激素
内科学
内分泌学
生理学
生物
睾酮(贴片)
基因
遗传学
乙酰化
肾
作者
Qiyu Bao,Jie Pan,Hangfei Qi,Lu Wang,Qian Hua,Fangzhen Jiang,Zewei Shao,Fengzhi Xu,Zhiping Tao,Qi Ma,Peter J. Nelson,Xueqing Hu
标识
DOI:10.1016/j.mce.2014.07.005
摘要
Aging represents an important health issue not only for the individual, but also for society in general. Burdens associated with aging are expanding as longevity increases. This has led to an enhanced focus on issues related to aging and age-related diseases. Until recently, anti-aging endocrine-therapy has been largely limited to hormone-replacement therapy (HRT) that is associated with multiple side effects, including an increased risk of cancer. This has greatly limited the application of HRT in anti-aging therapy. Recently, the focus of anti-aging research has expanded from endocrine signaling pathways to effects on regulatory gene networks. In this regard, the GHRH-GH-IGF-1/Insulin, TOR-S6K1,NAD+-Sirtuin, P53, Klotho and APOE pathways have been linked to processes associated with age-related diseases, including cancer, cardiovascular disease, diabetes, osteoporosis, and neurodegenerative diseases, all of which directly influence health in aging, and represent key targets in anti-aging therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI